Deep Brain Stimulation

Project description

Deep brain stimulation is a neurosurgical treatment involving the permanent implantation of electrodes
in the brain, to stimulate a specific deep structure. Electrical stimulation of some brain structures treats
symptoms of motor or affective neurological disorders. The success of the operation relies on the elec-
trode placement precision, which the goal is to maximize the therapeutic outcomes, and minimize the
adverse effects. To do that, a pre-operative planning step determine the target coordinates to stimulate,
as well as the electrode trajectory to reach it, thanks to a combination of medical images of the patient
and numerical tools. However, intra-operative brain deformation, called brain shift, might invalidate the
planning.
This project rely on a biomechanical model of brain shift which comprises a mechanical model for deformation, as well as a model of cerebrospinal fluid leak. We present a pre-operative tool, based on our model, in order to provide to the surgeon an information on the deformation risks, that he could use to select a safe trajectory for the patient, even in the case of
brain shift. Moreover, we propose an intra-operative registration method based on our biomechanical model, in order to compute the new location of anatomical structures. Finally, thanks to a model of insertion of the electrode and its interaction with brain tissue, we reproduce the operating protocol in order to compute the electrode curvature due to brain shift.

Results