Deep Brain Stimulation Planning

Project Info

Funding Inria

Objective Deep Brain Stimulation

Contact stephane.cotin@inria.fr

Collaborators

People Involved

Project Description

Deep brain stimulation is a neurosurgical treatment involving the permanent implantation of electrodes in the brain, to stimulate a specific deep structure.

Electrical stimulation of some brain structures treats symptoms of motor or affective neurological disorders. The success of the operation relies on the electrode placement precision, for which the goal is to maximize the therapeutic outcomes, and minimize the adverse effects.
To do that, a preoperative planning step determine the target coordinates to stimulate, as well as the electrode trajectory to reach it, thanks to a combination of medical images of the patient and numerical tools.
However, intraoperative brain deformation, called brain shift, might invalidate the planning.
This project relied on a biomechanical model of brain shift which comprises a mechanical model for deformation, as well as a model of cerebrospinal fluid leak.
We presented a preoperative tool, based on our model, in order to provide the surgeon with an information on the deformation risks, that he could use to select a safe trajectory for the patient, even in the case of brain shift.
 
Moreover, we proposed an intraoperative registration method based on our biomechanical model, in order to compute the new location  of anatomical structures.
 
Finally, thanks to a model of insertion of the electrode and its interaction with brain tissue, we reproduced the operating protocol in order to compute the electrode curvature due to brain shift.

Publications

Anticipation of Brain Shift in Deep Brain Stimulation Automatic Planning Noura Hamzé, Alexandre Bilger, Christian Duriez, Stéphane Cotin, Caroline Essert IEEE Engineering in Medicine and Biology Society (EMBC’15), Aug 2015, Milan, Italy. IEEE, pp.3635 – 3638 2015

Intra-operative Registration for Deep Brain Stimulation Procedures based on a Full Physics Head Model Alexandre Bilger, Éric Bardinet, Sara Fernandez-Vidal, Christian Duriez, Pierre Jannin, Stéphane Cotin MICCAI 2014 Workshop on Deep Brain Stimulation Methodological Challenges-2nd edition

Computation and visualization of risk assessment in deep brain stimulation planning Alexandre Bilger, Christian Duriez, Stéphane Cotin Studies in health technology and informatics 196, 2014 p. 29-35,

Intra-operative Registration for Deep Brain Stimulation Procedures based on a Full Physics Head Model Alexandre Bilger, Eric Bardinet, Sara Fernández-Vidal, Christian Duriez, Pierre Jannin, Stéphane Cotin MICCAI 2014 Workshop on Deep Brain Stimulation Methodological Challenges – 2nd edition, Sep 2014, Boston, United States. 2014

Brain-shift aware risk map for Deep Brain Stimulation Planning Alexandre Bilger, Caroline Essert, Christian Duriez, Stéphane Cotin DBSMC – MICCAI 2012 Workshop on Deep Brain Stimulation Methodological Challenges, Oct 2012, Nice, France. 2012

Biomechanical Simulation of Electrode Migration for Deep Brain Stimulation Alexandre Bilger, Jérémie Dequidt, Christian Duriez, Stéphane Cotin 14th International Conference on Medical Image Computing and Computer-Assisted Intervention – MICCAI 2011, Sep 2011, Toronto, Canada.

Thesis

Patient-specific biomechanical simulation for deep brain stimulation Alexandre Bilger Modeling and Simulation. Université des Sciences et Technologie de Lille, 2014. English

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